diff --git a/drivers/iio/chemical/bme680_core.c b/drivers/iio/chemical/bme680_core.c
index 500f56834b01..a6bf689833da 100644
--- a/drivers/iio/chemical/bme680_core.c
+++ b/drivers/iio/chemical/bme680_core.c
@@ -10,6 +10,7 @@
  */
 #include <linux/acpi.h>
 #include <linux/bitfield.h>
+#include <linux/cleanup.h>
 #include <linux/delay.h>
 #include <linux/device.h>
 #include <linux/module.h>
@@ -52,6 +53,7 @@ struct bme680_calib {
 struct bme680_data {
 	struct regmap *regmap;
 	struct bme680_calib bme680;
+	struct mutex lock; /* Protect multiple serial R/W ops to device. */
 	u8 oversampling_temp;
 	u8 oversampling_press;
 	u8 oversampling_humid;
@@ -827,6 +829,8 @@ static int bme680_read_raw(struct iio_dev *indio_dev,
 {
 	struct bme680_data *data = iio_priv(indio_dev);
 
+	guard(mutex)(&data->lock);
+
 	switch (mask) {
 	case IIO_CHAN_INFO_PROCESSED:
 		switch (chan->type) {
@@ -871,6 +875,8 @@ static int bme680_write_raw(struct iio_dev *indio_dev,
 {
 	struct bme680_data *data = iio_priv(indio_dev);
 
+	guard(mutex)(&data->lock);
+
 	if (val2 != 0)
 		return -EINVAL;
 
@@ -967,6 +973,7 @@ int bme680_core_probe(struct device *dev, struct regmap *regmap,
 		name = bme680_match_acpi_device(dev);
 
 	data = iio_priv(indio_dev);
+	mutex_init(&data->lock);
 	dev_set_drvdata(dev, indio_dev);
 	data->regmap = regmap;
 	indio_dev->name = name;